HERE ARE OUR MAIN RESEARCH PROJECTS
Photo by Maik Richter
RETROVIRAL RESTRICTION FACTORS
Restriction factors present roadblocks to the replication of retroviruses in cells. In this project, we use a simple retrovirus, the murine leukemia virus (MLV), as a model to study such retroviral restriction factors.
Photo by Maik Richter
ACUTE MYELOID LEUKEMIA THERAPY
One of the reasons for unsuccessful therapy of acute myeloid leukemia (AML) is the sub-optimal response to drugs. In this project, we want to investigate the use of lentiviral accessory protein Vpx to target SAMHD1, a protein contributing to resistance against the chemotherapeutic drug cytarabine in AML cells.
Photo by Maik Richter
RABBITS AS A MODEL FOR HIV INFECTION
Small animal models of HIV infection are needed for the effective development of treatment against AIDS or vaccines against HIV. Based on the observation that rabbits generally are more permissive to HIV infection, we want to study innate immune factors involved in viral immunity and develop a rabbit model of HIV infection.